Gorakh Raj Giri; Uddhav Timilsina

doi:10.3126/njb.v5i1.18869

Apoptosis: Implications in Viral and Mycobacterium tuberculosis infections

Gorakh Raj Giri
Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi
Uddhav Timilsina
Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi

Abstract

Apoptosis is a form of programmed cell death leading to genetically controlled self-destruction of cells. It is essential in the development, maintenance, and regulation of cells during physiological as well as pathological conditions. Deregulation of apoptotic mechanisms is associated with various pathological diseases including cancer, autoimmune disorders, viral and bacterial infections. Virus and Mycobacterium tuberculosis elicit host cell apoptosis as a part of host immune defense or pathogen dissemination. They inhibit both extrinsic and intrinsic pathways of apoptotic mechanisms facilitating pathogen survival and escape from host immune defense.

Nepal Journal of Biotechnology. Dec. 2017 Vol. 5, No. 1: 46- 57

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Published at

31. December 2017
https://doi.org/10.3126/njb.v5i1.18869
Issue:

Vol. 5 No. 1 (2017)
Section:

Review Articles
Keywords:

apoptosis virus Mycobacterium tuberculosis immune response
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Giri, G. R., & Timilsina, U. (2017). Apoptosis: Implications in Viral and Mycobacterium tuberculosis infections. Nepal Journal of Biotechnology, 5(1), 46–57. https://doi.org/10.3126/njb.v5i1.18869

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